Analogue techniques were applied to measurements of phasic aortic blood flow and pressure to obtain continuous recordings of peripheral vascular resistance and circulatory function in open-chest
dogs during basal narcosis with chloralose. Whereas the hypotension following hexamethonium 1 and 3 mg/kg i.v. was associated with a marked fall in peripheral vascular resistance
and some reduction of maximum acceleration and cardiac output, the hypotension during ventilation with 1 and 2% halothane was associated with a large reduction in maximum acceleration (i.e. cardiac depression)
and cardiac output with a relatively small fall in peripheral vascular resistance. In closed-chest dogs 1–2% halothane caused falls in arterial blood pressure and heart rate
similar to those after hexamethonium 1–3 mg/kg i.v. without comparable impairment of either vagally-induced bradycardia or the contractions of the nictitating membrane due to sympathetic nerve stimulation. Ganglion blockade did, however, become prominent with concentrations of 4% halothane. It is thought that diminished central vasomotor tone, a reduction of the effects of the sympathetic mediator on blood vessels and a direct relaxant effect of halothane on vascular smooth muscle also contribute importantly to the peripheral vascular depression.
OTHER LINKS:
http://bja.oxfordjournals.org/cgi/co...tract/45/5/416
http://www.lawyersweekly.ca/index.php?section=article&articleid=110
http://www.vetabusenetwork.com/news.htm
http://www.canadian-lawyers.ca/understand-your-legal-issue/other/1025044/
http://animal-law.lawyers.com/Veterinarian-Malpractice---Is-it-Worth-Suing.html
http://www.animallaw.info/articles/qvusvetmal.htm
http://www.ccac.ca/en/alternatives/refinement_raffinement/theme02.html
http://www.vancouveranimalwellness.com/anesthetic.html
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